α-Synuclein and LRRK2: Partners in Crime
نویسندگان
چکیده
In this issue of Neuron, Lin et al. report that LRRK2 modulates age-related neurodegeneration caused by overexpression of alpha-synuclein in the forebrain of transgenic mice. Overexpression of LRRK2 accelerates the progression of alpha-synuclein-mediated neuropathological changes, whereas deletion of LRRK2 alleviates these alterations. The results reveal an interesting interaction between alpha-synuclein and LRRK2, two gene products linked to dominantly inherited Parkinson's disease.
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ورودعنوان ژورنال:
- Neuron
دوره 64 شماره
صفحات -
تاریخ انتشار 2009